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A common polymorphism in HIBCH influences methylmalonic acid concentrations in blood independently of cobalamin Am J Hum Genet 2016;98:869-82

B12 supplementation addresses the nutrient depletion that can occur with reduced food intake and altered absorption

doi: 10.1089/neu.2006.23.635, 4 ChenJ.SongY.YangJ.ZhangY.ZhaoP.ZhuX.-J.et al
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( Given adenosine's role in energy regulation and neurotransmission, other metabolites involved in cellular metabolism, such as taurine, may also contribute to the disrupted energy balance seen in these conditions

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