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Science 1999;284:2177-81.ArticlePubMed 13

Furthermore, protease-activated receptor 2 (PAR2) signaling in melanocytes amplifies oxidative and inflammatory responses through the Akt/NF-B axis, elevating cytokine production and reducing antioxidant defenses, based on CAT and SOD activity, exacerbating skin inflammation 126

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Notably, the inter-atomic S-O distance between the H-site bound GSH and water molecule was 3.6 , which is slightly greater than the expected hydrogen bond length as a nucleophile