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gender and age were included as covariates

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Similarly, Berberine has been shown to inhibit CYP2D6 and CYP3A4, which can increase the risk of drug accumulation and toxicity when co-administered with tricyclic antidepressants, macrolide antibiotics, or calcium channel blockers

Science 347, 13621367, doi: 10.1126/science.aaa1299 (2015)

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[DOI] [PubMed] [Google Scholar] 75.Ruegsegger G
