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The preservation of lean body mass is particularly evident during periods of caloric restriction or aging, where GH helps maintain muscle tissue while preferentially mobilizing fat stores for energy

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Although targeted therapies have improved outcomes, resistance remains a challenge, particularly in high-risk patients with TP53 mutations or unmutated immunoglobulin heavy-chain variable region (IGHV) genes (U-CLL)

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Current therapies mainly focus on disease modification by immunosuppression, while no treatment specifically focuses on controlling cell death injury