glutathione enzyme inhibitor The Selenoprotein Peroxidase 4: From Molecular Mechanisms to Novel Therapeutic Opportunities Glutathione-Related Enzymes and Proteins: A

1989;257:L163L73

Rev Inst Med Trop Sao Paulo 57:315320

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Cellular Aging and Telomere Biology Epitalon has been shown in cell culture and animal models to activate telomerase, an enzyme that maintains and elongates telomeres the DNA-protective caps at the ends of chromosomes that naturally shorten with each cell division

However, under oxidative stress or pathological conditions like AGEs (72), Nrf2 is activated and translocated to the nucleus, initiating the expression of antioxidant genes such as GPX4, which are essential for reducing lipid peroxidation and delaying ferroptosis (73)

Saini S, Hindmarsh PC, Matthews DR, Pringle PJ, Jones J, Preece MA, Brook CG