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Most chemotherapeutic drugs, including taxane and platinum, are known to generate oxidative stress and elevate levels of LPO-derived aldehydes

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Although superoxide (O 2 .- ) initiated cascades of reactions are important in clearing foreign pathogens, largely within the safe confines of the phagocytic vacuole, sustained NADPH oxidase (NOX) activation is considered to result in adverse effects on the host [3]