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The best thing to do would be to use a sublingual form, so that the B12 gets absorbed that way and bypasses the digestive route
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doi: 10.1111/imr.12160 39 YueXTrifariSijTTsagaratouAPastorWAZepeda-MartnezJAet al
Loureno SC, Moldo-Martins M, Alves VD
Some randomized controlled trials combining topical + oral glutathione observed statistically significant improvements in skin brightness and melanin index around 8 weeks

doi:10.1186/s12916-025-04276-8 Lu XT, Wang YN, Mo QW, et al