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As H 2 O 2 and superoxide (O 2 ) ions have been reported to have an inhibitory effect on SOD and catalase activities, respectively, the authors have suggested that riboflavin deficiency may lead to an overproduction of reactive oxygen species (obviously through a mechanism independent of the glutathione redox cycle) beyond the scavenging ability of SOD and catalase

Common KD adverse effects include metabolic abnormalities, gastrointestinal symptoms, kidney stones, and slow growth in children (232)

Pinheiro LC, Oliveira-Paula GH

Pharmaceuticals and microplastics pose significant risks to water quality and aquatic life due to their bioactivity and toxic metabolites ( Ibuprofen is commonly detected in surface waters at concentrations ranging from ng/L to g/L

Some argue this sustained elevation is less physiological and may carry more risk over time

Topiramate can induce cytochrome P450 (CYP) 3A4 and inhibit CYP2C19