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Dosage may be reduced to 0.5 mL weekly in patients experiencing gastrointestinal intolerance or increased to a maximum of 2 mL twice weekly for short-term metabolic intensification when supervised by a qualified clinician

Since B12 and intrinsic factor HAVE to be absorbed together this can make for a difficult situation

There is no published, adequately powered CagriSema trial using biopsy-defined liver endpoints

Children generally require weight-adjusted regimens, often 100 mcg monthly after initial loading

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Microbes in Gastrointestinal Health and Disease
