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Their relative efficacy depends on absorption, bioavailability, dose, duration, and individual hepatic capacityall factors that vary significantly across populations and genetic backgrounds

Bloem et al., 2007

A researcher who administers a high-quality, accurately dosed peptide systemically every single day is likely to see more significant results than someone who haphazardly attempts localized injections with a questionable product

This is consistent with another study that showed a disparity between HO-1 protein and HO activity in a rat model of metabolic syndrome where HO-1 protein was likely modified by nitrosylation resulting in decreased functionality (Kruger et al., 2006)

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For severe cases, options include laser therapy or vitrectomy surgery