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If simple measures do not provide relief within two to three weeks, further medical review is appropriate to exclude other causes and consider alternative supplementation routes

I would say about 75-80% of patients will get some positive response from these medications, but these meds do have a really long list of side effects, which often leads to discontinued use

We need more research to know for sure

Uncertain Effectiveness : Promising animal data do not prove reliable human benefit, and limited clinical evidence prevents firm conclusions about recovery, pain, or tissue repair outcomes