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A B12 injections effect can last anywhere from a couple of weeks to a few months, and the difference comes down to why you are deficient, how well your body holds on to B12, and the dose and schedule you are on

If you have an MTHFR mutation you are a candidate for B12 shots

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Good digestive health: Good Digestive Health-Picture Courtesy: Australian Pet Organics Inadequate amount of vitamin b12 causes digestive issues, which have discussed earlier