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Notably, certain microbial metabolites (e.g., butyrate and acetate) have been shown to reduce proinflammatory cytokines [interleukin (IL)6, IL-12, IL-17, and interferon (IFN)-], while enhancing anti-inflammatory cytokines (transforming growth factor- and IL-10), consequently modulating SLE disease activity [10]

In addition to these effects, salicylates also uncouple oxidative phosphorylation, meaning that some of the proton gradient across the mitochondrial matrix is dissipated in the formation of heat, rather than ATP, forcing the production of lactate

Because the field is composed predominantly of observational and single-arm trials, the risk of publication bias toward positive associations is acknowledged

& Higgins, G

Adipose tissue and metabolic alterations: regional differences in fat cell size and number matter, but differently: a cross-sectional study

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