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6/1-4 The modified frailty index does not correlate with sarcopenia in patients undergoing elective transforaminal lumbar interbody fusion (TLIF) surgery

In OC, various ADCs targeting antigens such as folate receptor alpha (FR), trophoblast cell surface antigen 2 (TROP-2), mesothelin (MSLN), sodium-dependent phosphate transport protein 2B (NaPi2b), and human epidermal growth factor receptor 2 (HER2) have shown encouraging preclinical results and significant clinical activity

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Nach der Aktivierung des IGF-1-Rezeptors werden zwei Hauptsignalwege ausgelst: PI3K/Akt, der die Proteinsynthese antreibt und den Abbau hemmt, sowie MAPK/ERK, der die Zellproliferation stimuliert