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[DOI] [PMC free article] [PubMed] [Google Scholar] Rothschild, D

2016;11(9):e0162590

Modern lifestyle habits may include poor dietary choices, lack of sleep, abundance of stress, exposure to chemicals, and even extremes with exercise

Preliminary findings after one year indicated the program was associated with reduced symptom severity and improved quality of life

Notably, the protective effects of irisin were abated by the administration of the SIRT1 inhibitor EX527 in vivo or by siRNA-mediated knockdown of SIRT1 in vitro
