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Each group of MA self-administration, extinction, and reinstatement induces distinct changes in the metabolic pathways, particularly those related to the TCA cycle, arginine and proline metabolism, and arginine biosynthesis

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We have to look at these and say, okay, moderation is the key

Furthermore, mean gray value per mm 2 , indicating the immunofluorescence signal from regions of interest, were comparable in L-ZSF1 (0.05 0.0025) and O-ZSF1 rats (0.04 0.0035, p = 0.095) (Fig