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The first step (for all OA patients) is following an anti-inflammatory diet (mainly the MD, rich in -3 PUFAs, fruits, vegetables, and whole grains), combined with weight loss of 510% (for those with a BMI 25) and low-impact exercises (such as swimming) for 3 months
Spine 27(22): 2499-2502, 2002
Yet their heterogeneity and uncertain causality highlight the need for integrated clinical and translational studies to clarify whether mitochondrial remodeling represents a therapeutic target or primarily a disease marker
10.1007/s11010-007-9418-5 [DOI] [PubMed] [Google Scholar] Sen S., Kar M., Roy A., Chakraborti A
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It has been demonstrated that excessive mitochondrial fission or fragmentation is a factor in the pathology of amyotrophic lateral sclerosis (ALS)
