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Proc Natl Acad Sci U S A 120(18):e2221888120

However, both variants showed a specific defect on long chain triglyceride substrates, suggesting the pore observed in our structure has physiological relevance for hydrolysis of specifically long chain ligands

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These data were supported by functional studies, and we found that ALCAR can inhibit hallmarks of tumour progression in vitro, by limiting PC-3, LNCaP, DU145 and BPH cell adhesion, migration and invasion

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