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A 2023 pharmaceutical review cautioned that BPC-157 increases VEGFR2 expression and that VEGF pathways are active in many human cancers

SamuelBSShaitoAMotoikeTReyFEBackhedFManchesterJKet al
doi: 10.1038/s41467-023-36209-5, [DOI] [PMC free article] [PubMed] [Google Scholar] Yellen G

This is one of the main reasons the two are paired together rather than administered separately

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They can also keep you for a while and monitor for side effects
