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Patel, S., Gielecki, J., Loukas, M

For the Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R), a mean slope of 1.0 was observed in the treated group compared to 1.4 in the untreated patients ( p = 0.0575)

doi: 10.1111/eci.12960

This leads to an accumulation of catecholamines at the synaptic level, resulting in prolonged stimulation of adrenergic receptors

Seelig, AD

Glutamate acts through eight ionotropic and metabotropic receptor subtypes (mGluR1mGluR8) that have been classified into three groups: Group I receptors (mGluR1 and mGluR5) are coupled to G q proteins and phospholipase C and are involved in central sensitization and pain chronification