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Although reprogramming has historically used viral vectors, recent advancements in microRNA technology has led to the development of alternative transcription factor delivery methods that have been reported to increase the conversion efficiency in vitro and in vivo from somatic cells into functional dopaminergic neurons and ameliorate motor symptoms in a model of PD

60 (Suppl 7): 161-165

In cosmetic protocols it is applied twice daily as a serum or cream for a minimum of 8 weeks for measurable effect

The FDA has begun to crack down on the worst compounding pharmacies making this stuff

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