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These indirect effects suggest that isotretinoin may modulate, restore dysregulated endocrine and metabolic signaling within the sebaceous gland, counteracting exposome-driven hormonal overstimulation (376, 377)

Pain intensity was evaluated by means of a visual analogue scale (VAS) [ 10-point visual analogue scale: 0 = no pain

REACTION: R05267 (KEGG) Couto, Narciso

The cDNA was synthesized using Im-Prom II reverse transcriptase (Promega, Fitchburg, WI), as recommended by the manufacturer

Biol Plantarum 49(1):85 Sakuma YK, Maryyama F, Qin Y, Osakabe K, Shinozaki KY, Yamaguchi S (2006) Dual function of an Arabidopsis transcription factor dreb2a in water-stress-responsive and heat-stress-responsive gene expression