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Park and collaborators introduce a novel -lipoic acid nanoparticulate formulation developed through nano-comminution, employing different polymeric stabilisers (hydroxypropyl cellulose, Pluronic F127, and polyvinylpyrrolidone)

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This suggests that either the rate of release of EBN/ SG from its complex with -Me-CD was higher than from -CD, presumably due to decreased hydrogen bonding between methylated OH groups and the nitroxide, or to the methyl groups obstructing its inclusion in the cyclodextrin