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It is likely that the addition of external CYP2E1 load into an in vitro system will exacerbate CYP2E1-mediated toxicity in U1 cells

Suh HS, Chang MS, Yu I, et al

Organogenesis 2: 2227, 2005 [DOI] [PMC free article] [PubMed] [Google Scholar] 7

Several cytokines like interleukin 1, 6, tumor necrosis factor- and transforming growth factor- induces transcriptional upregulation of both HGF residing in fibroblasts and macrophages and c-MET residing in epithelial cells [30]

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Polyphenols possess potent antioxidant capacity attributed to their ability to donate hydrogen and electrons, thereby stabilizing cellular oxidation and mitigating oxidative damage by terminating the reaction between ROS/RNS