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Substance P stimulation of polyphosphoinositide hydrolysis in rat anterior pituitary membranes involves a GTP-dependent mechanism

Systemic inflammation can trigger hepcidin synthesis by inducing the expression of proinflammatory cytokines, mainly IL-6, which activate HAMP (gene for HEP) expression (Wrighting and Andrews, 2006[455]), resulting in decreased iron absorption and sequestration of iron in macrophages, which explains the anemia observed in chronic disease (Weinstein et al., 2002[450])

The activation of the mTOR signaling pathway, which is commonly observed in thyroid cancer, promotes amino acid metabolism by upregulating amino acid transporters and amino acid metabolic enzymes [35]