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We also observed increased gene expression levels of Transferrin receptor 1 ( TfR1) in all four cancer cell lines relative to HThF (Fig

However, most of the activity is in the cytosolic fraction (Cooper and Meister, 1981), and most of the -lyase activity toward DCVC in rat kidney mitochondria could not be assigned to GTK (Abraham et al., 1995)

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The results of a clinical study further confirmed this observation by showing that patients with nonmetastatic lung cancer harbored loss-of-function mutations in SDH5 128

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