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In the case of LC, there is increased levels of depleted T cells (PD-1+/Tim-3+) [128], impaired T-cell function [119, 128], decreased recruitment of activated T cells [125], impaired cytotoxic response of NK cells [373], increased Th2 response [128], increased Treg cells [374376], increased proinflammatory cytokines (IFN-, TNF, IL-1, and IL-6) and IL-10 [118, 125, 377, 378], increased oxidative stress [377, 379381], decreased antioxidant defenses [380], hypozincemia [380, 382], hypocortisolism [128, 133, 141143], presence of amyloid fibrin microbleeds [33, 146149], presence of transient autoantibodies (ANAs, ANCA and anti-cardiolipin) [106, 113, 383, 384], insulin resistance [385, 386], and increased IDO activity and kynurenine levels [387]

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doi: 10.1210/er.2001-0034 8 SchomburgL

While supplements may be appropriate for some people, they may not be safe for everyone, and they could interact with other medications a person is taking