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Cleavage of the C-terminal NCI domain of type XV collagen results in the production of restin, a molecule shown to possess antiangiogenic properties in vitro by inhibiting bFGF-induced EC migration and in a xenograft carcinoma model in vivo 107,108

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In the second protocol, HUVECs (410 4 cells per well) in complete media were simultaneously seeded with DMSO or BPC-157 (1 g/mL, 5 g/mL, and 10 g/mL) in matrigel-coated plates

FDA regulatory shifts in 2023 to 2024 moved BPC-157 and other compounds to "Category 2" status, requiring strict 503A/503B medical-grade sourcing for legal clinical use