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Dysregulation of mitochondrial calcium (mtCa) uptake, particularly due to MICU1 deficiency, leads to progressive muscle weakness and atrophy in both patients and mouse models [293]

LA maintains the cellular antioxidant state indirectly through activating the NRF2 pathway, and the NRF2 pathway governs the expression of antioxidant genes (such as -glutamylcysteine synthetase (-GCL), NAD(P)H quinone oxidoreductase 1 (NQO-1), and superoxide dismutase (SOD)) for enhancing the cell's antioxidant capacity and anti-inflammatory response [34, 35]

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Per la maggior parte delle persone, l'acetil-L-carnitina e la L-carnitina tartrato sembrano essere le forme pi efficaci per un uso generale

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