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Funding This study was funded by National Natural Science Foundation of China (82270085), the Natural Science Foundation of Guangdong Province (2021A1515012565), the Open project of State Key Laboratory of Respiratory Disease (SKLRD-OP-202201)

BPC-157 is a synthetic 15-amino-acid peptide (sequence GEPPPGKPADDAGLV) that corresponds to a fragment of a protein found in gastric juice, first characterized in 1993

Ferroptosis suppressor protein 1 (FSP1) reduces coenzyme Q10 (CoQ) by utilizing nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) to generate CoQH 2 , a radical-trapping antioxidant (RTA) that traps lipid peroxyl radicals and thus inhibits ferroptosis (Doll et al., 2019

The primary interactions between Epitalon molecules and dendrimers transpired between the positively charged NH 3 + groups of the dendrimer and the negatively charged COO groups of glutamic acid and asparagine in Epitalon peptides

PD-1 deficiency and PD-1 blockade in tumor model study indicated that mitochondrial functions, including ROS generations, are upregulated in vivo following obliteration of PD-1 signaling [66]

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