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Furthermore, the specific inhibition of NNMT by 5-amino-1mq avoids interference with other metabolic enzymes, ensuring the specificity and reliability of experimental results

It activates AMPK signaling (the same pathway activated by exercise and caloric restriction), improves insulin sensitivity, enhances glucose uptake by muscle tissue, and supports mitochondrial biogenesis

Mice underwent longitudinal in vivo two-photon imaging of V1 to allow for tracking of oligodendrocyte loss and gain throughout the demyelination and remyelination periods (Fig
