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Interestingly, like oxaliplatin (this study), MMC can also be detoxified by glutahthione [44], suggesting that the combination treatment strategy identified in the present study may be beneficial for both oxaliplatin- and MMC-based HIPEC

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H2S is another DNA-damaging mutagen, but it exerts an anti-inflammatory effect by facilitating the polarization of M2 macrophages, i.e., it has the advantage of both NO and CO, which can diminish the negative effects of PTT while improving the therapeutic effect and eliminating the biofilm

continued using Bmal1 knockout mice and reported altered clock gene expression (Cry2 and Per2) along with decreased Nrd1, Dbp, Il1 , and Nox2 expression and increased Gsr and Lpl expression, indicating that Bmal1 regulates immune response and cellular metabolism in microglia (Wang et al., 2020)

With the Warburg effect, he described the metabolic shift in cancer cells from oxidative phosphorylation to an increased rate of aerobic glycolysis, to produce significantly higher amounts of ATP [46]

As we age, we experience a decline in the production of keratin and those with poor diets can have even a more dramatic reduction in keratin production