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Defective autophagy leads to increased DNAdamaging reactive oxygen species production, genomic instability, and generalized inflammation which can promote tumor initiation (Komatsu et al., 2007

, In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD animal model, ceftriaxone, a -lactam antibiotic known to enhance GLT-1 expression, exhibited neuroprotective and behavioral benefits, including improved cognitive function

doi: 10.1016/S0140-6736(20)30367-6 46 LivingstonG.SommerladA.OrgetaV.CostafredaS

Front Biosci 2012;E4:1335-44

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For example, supplementation with vitamin D (60,000 IU of vitamin D orally once weekly for 1 month, and then 60,000 IU once a month for the next 2 months) and calcium (1000 mg/day) decreased chronic non-specific musculoskeletal pain in a study conducted on 50 hypovitaminosis D patients [104]