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Vaccaro, J

However, under oxidative stress, cysteine residues on KEAP1 are modified, altering its conformation and disrupting its association with NRF2 and subsequent NRF2 stabilization (Taguchi and Yamamoto, 2017)

The Journal will publish the AOP reviewed through the Journal Format Article

Elevated ROS levels increase vascular permeability and leakage of plasma components, contributing to the development of retinopathy [184]

Technical factors also influence interpretation: NF-B activity is best judged by its nuclear translocation or phosphorylation, and IHC for total NF-B may overrepresent localized inflammatory foci 40 , and platelets can promote thrombo-inflammatory interactions with neutrophils, monocytes, and T cells during ischemiareperfusion injury