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98 In fact, macrophages are heterogeneous and derive from different ontological origins during liver damage: resident yolk sac-derived macrophages, also known as Kupffer cells (KCs), and circulating bone marrow MoMFs

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10.1111/j.1439-0272.2008.00897.x 100

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This means consistent use over multiple cycles can continue to produce benefits without needing to increase the dose

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