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Data extraction and synthesis The following data were extracted for each included study

In an attempt to block glycine biosynthesis, researchers are using antimetabolites (drugs that interfere with the effects of metabolites), methotrexate, and pemetrexed to inhibit SHMT [134, 141]

Medical conditions such as chronic gastritis (inflammation of the stomach) or gastrectomy (partial or total surgical removal of the stomach) can leave the body without enough intrinsic factor

Due to its amphiphilic structure, ALA is soluble in both aqueous and lipidic environments

SS-31 addresses this fundamental bottleneck

Mol Cancer Ther 6(7):21032112 Wang C, Youle RJ (2009) The role of mitochondria in apoptosis*