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The first publications reported enzyme activity involving displacement of a halide ion from an aromatic compound, resulting in an S-substituted glutathione conjugate ( GSTs were first recognized as enzymes inactivating xenobiotics, in particular electrophilic mutagens and carcinogens, leading to their excretion as mercapturic acids ( An independent set of reports identified a remarkably abundant protein in liver with affinity for carcinogens, steroid hormones, bilirubin and synthetic dyes

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Adhesion molecules: key players in mesenchymal stem cell-mediated immunosuppression

It is becoming apparent that Nrf2 may be specifically down-regulated in certain cell types during development and differentiation, possibly because high levels of expression of the ARE-gene battery would compromise certain ROS-based signaling pathways

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