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Epigenetic modification of mtDNA has also been corroborated as a latent factor contributing to base mismatch in mtDNA during the pathogenesis of DR [341]

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These substances may not be detectable using standard immunoassays, necessitating more advanced chromatographic techniques, such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS)

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