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METHODS We assessed the activated bypassing pathways between the inferior and superior caval veins and portocaval shunt, counteracted caval/portal hypertension, aortal hypotension, venous/arterial thrombosis, electrocardiogram disturbances, liver and gastrointestinal lesions ( i.e ., stomach and duodenum hemorrhages, in particular, congestion)

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A conjugate according to claim 3, wherein in the derivative of formula I R 3 is H, R 4 is benzyl, and R 5 is phenyl

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