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In general, lactylation can be regulated by targeting enzymes that affect lactate metabolism and transport

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Ursodeoxycholic acid (UDCA) has been found ineffective for pruritus relief in primary sclerosing cholangitis and primary biliary cholangitis but is recommended for treating pruritus in intrahepatic cholestasis of pregnancy only, at doses of 1015 mg/kg/day, divided into 23 doses

Clostridium perfringens alpha-toxin impairs lipid raft integrity in neutrophils

Similarly, Chee et al.[8] found that increasing skeletal muscle L-carnitine content by 20% in older adults enhanced whole-body fat oxidation by 20% during moderate-intensity exercise, primarily through greater intramyocellular lipid utilization