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This work was supported by the Exploration project of Natural Science Foundation of Zhejiang Province (LTGY23H270009, LTGY24H270006)
In PC12 cells, exposure to dopamine resulted in a marked disruption of mitochondrial bioenergetic functions, leading to an approximately 40% decrease in cell viability, along with signs of apoptotic nuclear alterations and heightened activities of caspase 3 and caspase 9
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The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency
