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doi: 10.1172/JCI99397

Ionizing radiation (IR) is another source of ROS

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In COPD, repeated exposure to noxious particles, usually cigarette smoke, can activate epithelial cells and macrophages to release variety of chemotactic factors that attract inflammatory cells (eg, CD8 + T lymphocytes, neutrophils, monocytes) to the lungs, triggering a distinct inflammatory cascade in the small airways and lung parenchyma

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