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Another study found that TSA considerably inhibits Ang II-induced activation of CFs and -SMA production in vitro, while reducing collagen I/II and TIMP1/4 expression (132)

Sep-Oct 2021;96(5):539-543

Endogenous synthesis of Gln under hypoxic conditions was rate-limiting relative to normoxia where only maximal oxygen consumption rate (OCR) was sensitive to GLS inhibition, and inhibition of GLS or glutamine synthetase (GS) reduced basal and maximal OCR (54)

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& Chiang, J

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