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Moreover, hyperglycemia can promote non-enzymatic glycation of proteins, such as LDL [22], and increase the susceptibility of LDL to oxidation, which, once oxidized, can initiate or facilitate the progression of atherosclerosis [23]
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In addition to activation by PERK as part of the UPR, eIF2-ATF4 can also be activated by other stress sensors, including GCN2, PKR and HRI, collectively referred to as the Integrated Stress Response (ISR) 46
(October 2007)
SiO(2)@Au nanoshell-assisted laser desorption/ionization mass spectrometry for coronary heart disease diagnosis
