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Geroprotective and Anticarcinogenic Activity Lifetime Murine Studies Long-term studies in mice demonstrated that DSIP administration over a lifetime decreased total spontaneous tumour incidence 2.6-fold compared to untreated controls, slowed age-related switching-off of oestrous function, decreased the frequency of chromosome aberrations in bone marrow cells by 22.6%, and increased maximum lifespan by 24.1% compared to control groups a multi-parameter geroprotective profile that is among the most striking reported for any short regulatory peptide, and that has generated sustained interest in the DSIP analogue research field

PMID: 35105939 Nat Metab The alternative activity of nuclear PHGDH contributes to tumour growth under nutrient stress

Copper metabolism also warrants cycling consideration

Overview of episode topics [1:45]

For example, if you administer two separate drugs, but use three injections to administer them, you would report two injections (96372, 96372-59 Distinct procedural service, and the drug supply codes)

Active malignancy is a contraindication because NAD+ supports cellular proliferation