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Tissue composition inside the VOIs was calculated based on the T1-weighted image segmentation using Gannet 3.0

Toxicol Lett 172:2128 Van Veld P, Ko U, Vogelbein W, Westbrook D (1991) Glutathione S -transferase in intestine, liver and hepatic lesions of mummichog ( Fundulus heteroclitus ) from a creosote-contaminated environment

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It inhibits GSH depletion, GPX4 degradation and lipid peroxidation, increases Nrf2, and inhibits 12/15-LOX (Xie et al., 2016

There was no significant difference in the cytotoxic effects of 3-BP between cetuximab-resistant cell lines (HCT116(KRAS G13D/- ), DLD-1(KRAS G13D/- ), HT29(BRAF V600E ), RKO(BRAF V600E/-/- ), Caco-2-CR) and their paired cetuximab-sensitive cell lines (HCT116(KRAS wt/- ), DLD-1(KRAS wt/- ), HT29(shBRAF), RKO(BRAF wt/-/- ), Caco-2), indicating that the cytotoxic effect of 3-BP in these CRC cell lines is independent of their response to cetuximab