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Illustratively, BPC 157 may interfere with NO-system activities (Sikiric et al., 2014) and counteract harmful events, arising from either NO-blockade (L-NAME-application) or L-arginine (NOS-substrate-application) (Sikiric et al., 2014)

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In rare cases, it can also cause serious cardiovascular side effects, including heart attack, stroke, and sudden cardiac death (heart suddenly stops beating)

Actigraphy can supplement self-reported sleep diary information or be useful in situations of neurodevelopmental disorders where a sleep diary cannot be completed

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Manuscript source: Unsolicited manuscript Peer-review started: October 7, 2019 First decision: November 27, 2019 Article in press: January 19, 2020 Specialty type: Gastroenterology and hepatology Country of origin: Croatia Peer-review report classification Grade A (Excellent): 0 Grade B (Very good): 0 Grade C (Good): C Grade D (Fair): 0 Grade E (Poor): 0 P-Reviewer: Dragoteanu MN S-Editor: Ma YJ L-Editor: A E-Editor: Wu YXJ Contributor Information Slaven Gojkovic, Departments of Pharmacology and Pathology, Medical Faculty University of Zagreb, Zagreb 10000, Croatia