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Zhang J

10.1007/s00508-015-0742-6 [DOI] [PubMed] [Google Scholar] Miller A., Shapiro S., Gershtein R., Kinarty A., Rawashdeh H., Honigman S., et al

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A lifetime of muscle movement gives you a tired or angry look when the furrows on your brow or the laugh lines around your lips deepen

It is frequently undiagnosed because the primary symptom is snoring combined with daytime sleepiness, which many men normalise

A role for neuronal NHR-49 in longevity is supported by tissue-specific rescue studies of lifespan in a double mutant of nhr-49 with the long-lived, germline less glp-1/Notch receptor mutant: although expression of NHR-49 from intestine, hypodermis, and body wall muscle specific promoters all partially rescued glp-1 longevity, expressing NHR-49 pan-neuronally completely restored long lifespan (Naim et al., 2021)
