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Studies demonstrated that DSIP administration could elevate pain thresholds in animal models and provided some pain relief in clinical studies of chronic pain patients

These studies provide insight into the involvement of group II mGlu receptors in drug-induced neuroadaptations as well as a potential mechanism by which mGlu 2/3 could be targeted for therapeutic purposes

[DOI] [PubMed] [Google Scholar] 134.Dexter D.T., Ward R.J., Wells F.R., Daniel S.E., Lees A.J., Peters T.J., Jenner P., Marsden C.D

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Yet this new work shows that under the extreme energetic load of hypertrophic cardiomyopathy (HCM), CK becomes the weak link : hypercontractility and mitochondrial oxidative stress inactivate CK, breaking the hearts energy relay