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540 Treatment with toripalimab resulted in an ORR of 20.7% in patients with advanced melanoma, most of which are acral and mucosal melanoma
Furthermore, AS-IV helps maintain osteo-vascular homeostasis by attenuating oxidative stress and inhibiting apoptosis through activation of the Akt/Nrf2/HO-1 pathway (Shan et al., 2023

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Actin is one of the most abundant proteins in the body, so anything that influences it tends to have wide-ranging effects
